Modified from my original post at Discovering Biology in a Digital World.Why the ABRF of course!
Some DNA samples are more troublesome than others.
Luckily, when you have a group of people with members who sequence 25,000 DNA samples a month, or more, you also have a wealth of experience and knowledge that's invaluable when you encounter that one strange sample.
I think the members of the Association for Biomedical Resource Facilities (ABRF) are well-known for their willingness to help. From poor quality DNA to mixed samples, to mysterious or missing primers, They've seen it all and are willing to share strategies for solving the problem.
One of the really nice things, that the ABRF has developed, is the DNA sequencing Research Group's guide to trouble-shooting sequencing problems.
Are your arrays behaving strangely? Do you have weird things happen after long stretches of the same base? Are your customers asking you to use new techniques for SNP detection?
The ABRF is the place to go.
